PRE-EXISTING MINOR VARIANTS WITH NS5A L31M/V-Y93H DOUBLE SUBSTITUTION ARE CLOSELY LINKED TO VIROLOGIC FAILURE WITH ASUNAPREVIR PLUS DACLATASVIR TREATMENT FOR GENOTYPE 1B HEPATITIS C VIRUS INFECTION.

BackgroundL31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution Rangehood Filter Material positions associated with resistance to direct-acting antiviral (DAA) treatment.MethodsWe analyzed the frequency of NS5A L31M/V and Y93/H in NS5A inhibitor-naive HCV genotype 1 patients who received asunaprevir plus

The incidence of melanoma has been dramatically increasing over the last decades.Melanoma is considered to have a high metastatic potential and it can progress due to hematogenous metastasis or via lymphatic vessels.Different patterns of recurrence have been described, namely, local, satellite, and in transit metastasis (LCIT), lymphatic, and syste

Dynamic imaging has obtained remarkable achievements among a variety of malignant tumors due to the development of multiple simplified scanning protocols and the emergence of whole-body PET/CT scanners, which promote wider application of dynamic PET/CT.In this paper, we mainly review the acquisition protocols of dynamic imaging, related kinetic par

Peer reviewers at many funding agencies and scientific journals are asked to score submissions both on individual criteria Jump Box and overall.The overall scores should be some kind of aggregate of the criteria scores.Carole Lee identifies this as a potential locus for bias to enter the peer review process, which she calls commensuration bias.Here

With the continuous advancement of target detection technology in remote sensing, target detection technology in images captured by drones has performed well.However, object detection in drone imagery is still a challenge under rainy conditions.Rain is a common severe weather condition, and rain streaks often degrade the image quality of sensors.Th